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KMID : 0606920150230030238
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Biomolecules & Therapeutics
2015 Volume.23 No. 3 p.238 ~ p.244
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Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes
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Kang Na-Jin
Koo Dong-Hwan
Kang Gyeoung-Jin
Han Sang-Chul
Lee Bang-Won
Koh Young-Sang
Hyun Jin-Won
Lee Nam-Ho
Ko Mi-Hee
Kang Hee-Kyoung
Yoo Eun-Sook
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Abstract
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Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22 levels are elevated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflammatory lymphocytes to the skin. A major signaling pathway in the interferon-γ (IFN-γ)-stimulated inflammation response involves the signal transducers and activators of transcription 1 (STAT1). In the present study, we investigated the anti-inflammatory effect of dieckol and its possible action mechanisms in the category of skin inflammation including atopic dermatitis. Dieckol inhibited MDC/CCL22 production induced by IFN-γ (10 ng/mL) in a dose dependent manner. Dieckol (5 and 10 μM) suppressed the phosphorylation and the nuclear translocation of STAT1. These results suggest that dieckol exhibits anti-inflammatory effect via the down-regulation of STAT1 activation.
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KEYWORD
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Dieckol, Inflammation, Keratinocyte, MDC/CCL22, STAT1
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